Washington University in St. Louis

The Patti Lab
Metabolomics to elucidate novel biochemical mechanisms of disease
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Metabolomics Implicates Altered Sphingolipids in Chronic Pain of Neuropathic Origin

Patti GJ, Yanes O, Shriver L, Courade JP, Tautenhahn R, Manchester M, Siuzdak G
Metabolomics Implicates Altered Sphingolipids in Chronic Pain of Neuropathic Origin
Nature Chemical Biology, 8, 232-234, 2012
doi:10.1038/nchembio.767

Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic pain and that the upregulated, endogenous metabolite N,N-dimethylsphingosine induces mechanical hypersensitivity in vivo. These results demonstrate the utility of metabolomics to implicate unexplored biochemical pathways in disease.

Washington University, Departments of Chemistry, Genetics, and Medicine. Saint Louis, Missouri 63110 USA